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| + | The '''Aging Research Centre''' (ARC) is an independent [[non-profit]] educational research centre with facilities in [[Berkeley, California]] and in [[Waterloo, Ontario]], [[Canada]]. Founded in 1994, it focuses its research in three areas: (1) the assembling and linking together of existing knowledge with respect to the [[Senescence|aging process]] in animals, (2) engaging in experiments that shed light on the [[neuroendocrinology]] of aging, and the (3) creation of new tools that allow researchers to study the aging process. |
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| − | The '''American Aging Association (AGE)''' is a [[non-profit]], tax-exempt [[gerontology|biogerontology]] [[Organisation|organization]] of scientists and [[Layperson|laypeople]] dedicated to [[Health science|biomedical]] [[ageing|aging]] studies intended to slow the [[Senescence|aging process]]. The [[abbreviation]] '''AGE''' is intended to be representative of the organization, even though it is not an [[acronym]]. |
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| + | Throughout the years, researchers at the '''Aging Research Centre''' have presented their research results at many [[Academic conference|conference]]s and published numerous articles ranging from the effects of [[caloric restriction]] on the cell density in the pre-optic [[hypothalamus]], to the systems [[biology]] of aging, to articles on an [[Automated Imaging Microscope System]] (AIMS) that was developed by ARC researchers in collaboration with researchers at the [[University of California, Berkeley]]. |
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| − | ==History and Organization== |
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| − | AGE was founded in [[1970]] by [[Denham Harman]], MD,PhD, who is often known as the "father" of the "[[Free-radical theory|Free-Radical Theory of Aging]]". Dr. Harman was Executive Director of AGE for 20 years ([[1973]] to [[1993]]). |
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| + | ==Publications== |
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| − | Much of the early financial support for AGE came from [[Durk Pearson]] and [[Sandy Shaw]], who are known for their [[1982]] best-selling book ''Life Extension: A Practical Scientific Approach'' (ISBN 0-446-38735-5). |
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| + | * [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6J-4KGG1P4-C&_user=10&_handle=C-WA-A-VD-VD-MsSAYWB-UUW-U-U-VD-U-U-AADUEEDBAV-AAZYCDYAAV-WUBCCYBZA-VD-U&_fmt=full&_coverDate=02%2F28%2F2007&_rdoc=29&_orig=browse&_srch=%23toc%235032%232007%23999579998%23639966!&_cdi=5032&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e1fda3bc4b0ccb336fb38988703637d6 A computational systems biology approach to neuroendocrine aging: Initial results. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Page 142] |
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| − | The Vice-Presidency of AGE is to be a [[layperson]] position focused on promoting the scientific goals of AGE to the general public. |
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| + | * [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6J-4KGG1P4-B&_user=10&_handle=C-WA-A-VD-VD-MsSAYWB-UUW-U-U-VD-U-U-AADUEEDBAV-AAZYCDYAAV-WUBCCYBZA-VD-U&_fmt=full&_coverDate=02%2F28%2F2007&_rdoc=28&_orig=browse&_srch=%23toc%235032%232007%23999579998%23639966!&_cdi=5032&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2e1993c5025659810f6ce66fd3135f4f Novel methods in computer-assisted tissue analysis: Customized regional targeting of both cytoplasmic and nuclear-stained tissue. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 141-142] |
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| − | ==Activities== |
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| − | The primary activities of AGE are to |
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| + | * [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6J-4KGG1P4-10&_user=10&_handle=C-WA-A-VD-VD-MsSAYWB-UUW-U-U-VD-U-U-AADUEEDBAV-AAZYCDYAAV-WUBCCYBZA-VD-U&_fmt=full&_coverDate=02%2F28%2F2007&_rdoc=45&_orig=browse&_srch=%23toc%235032%232007%23999579998%23639966!&_cdi=5032&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d5741475a812c1d5a283114bba5379a8 Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 11-12.] |
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| − | #hold annual scientific conferences (every June) |
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| − | #give awards to researchers making significant contributions to the goals of AGE |
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| − | #promote interest among young scientists in the goals of AGE |
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| − | #publish newletters and journals |
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| + | * [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17194562&query_hl=3&itool=pubmed_docsum Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice. Int J Dev Neurosci. 2007 Feb;25(1):23-8] |
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| − | The [[Scientific journal|journal]] of AGE is called ''AGE'', and is published quarterly |
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| + | * [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17034982&query_hl=3&itool=pubmed_docsum Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice. Int J Dev Neurosci. 2006 Nov;24(7):431-6.] |
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| − | The 36th annual conference of AGE has been held June 1-4, [[2007]] in [[San Antonio, Texas]]. |
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| + | * [http://www.fasebj.org/cgi/content/meeting_abstract/20/4/A536?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&FIRSTINDEX=0&volume=20&issue=4&resourcetype=HWCIT A study of insulin-like growth factor-I receptor immunoreactivity in the supraoptic nucleus of young and old female B6D2F1 mice. FASEB Journal, April 2006, 357.5] |
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| − | ==See also== |
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| − | * [[Ageing]] |
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| − | * [[American Academy of Anti-Aging Medicine]] |
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| − | * [[Gerontology|Biogerontology]] |
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| − | * [[Life extension]] |
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| − | * [[List of life extension related topics]] |
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| − | * [[Senescence]] |
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| + | * [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15990721&query_hl=3&itool=pubmed_docsum Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice, Neuro Endocrinol Lett. 2005 Jun;26(3):197-203. ] |
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| − | *[http://www.americanaging.org/geninfo.html 2007 Annual AGE Meeting, General Information] |
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| − | *[http://www.americanaging.org/journal.html AGE: Journal of the American Aging Association] |
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| − | *[http://www.americanaging.org/news/AGE%20George%20Martin%20Discussion%20April%202005.pdf American Aging Association Debates on Aging Theory] |
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| + | * [http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6J-4DK6DF0-1-1&_cdi=5032&_user=10&_orig=browse&_coverDate=11%2F01%2F2004&_sk=999609988&view=c&wchp=dGLzVlz-zSkWW&md5=3b4c858a77ad92f1e24cbcf3c26e895e&ie=/sdarticle.pdf A survey of estrogen receptor-alpha immunoreactivity in the hypothalamus of young, old, and old-calorie restricted female B6D2F1 mice, Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1771] |
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| − | <!-- Categories --> |
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| − | [[Category:Aging]] |
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| + | * [http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6J-4DK6DF0-1-1&_cdi=5032&_user=10&_orig=browse&_coverDate=11%2F01%2F2004&_sk=999609988&view=c&wchp=dGLzVlz-zSkWW&md5=3b4c858a77ad92f1e24cbcf3c26e895e&ie=/sdarticle.pdf Protocal for higher resolution histological images of the mammalian brain, Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1770] |
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| − | [[Category:Anti-aging]] |
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| − | [[Category:Educational organizations]] |
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| + | * [http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6J-4DK6DF0-1-1&_cdi=5032&_user=10&_orig=browse&_coverDate=11%2F01%2F2004&_sk=999609988&view=c&wchp=dGLzVlz-zSkWW&md5=3b4c858a77ad92f1e24cbcf3c26e895e&ie=/sdarticle.pdf Towards a self-learning, self-assembling systemic map of neuroendocrine aging, Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1767] |
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| − | [[Category:Gerontology]] |
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| + | |||
| − | [[Category:Life extension]] |
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| + | * [http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6J-47PFF8R-2-1&_cdi=5032&_user=10&_orig=browse&_coverDate=01%2F31%2F2003&_sk=999619998&view=c&wchp=dGLbVzz-zSkzS&md5=8fdf809ce9f016009996765239c71491&ie=/sdarticle.pdf Phenomics: a new direction for the study of neuroendocrine aging. Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 218] |
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| − | [[Category:Non-governmental organizations]] |
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| + | |||
| + | * [http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6J-47PFF8R-2-1&_cdi=5032&_user=10&_orig=browse&_coverDate=01%2F31%2F2003&_sk=999619998&view=c&wchp=dGLbVzz-zSkzS&md5=8fdf809ce9f016009996765239c71491&ie=/sdarticle.pdf A comparison of estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged C57BL6 female mice. Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 220] |
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| + | |||
| + | * [http://www.sciencedirect.com/science?_ob=PublicationURL&_cdi=5032&_pubType=J&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=068c874a21c5a227d3977047c875f30c&jchunk=35#35 Creating Three-Dimensional Neuronal Maps of the Mouse Hypothalamus Using an Automated Imaging Microscope System. Experimental Gerontology, Volume 35 numbers 9-10, December 2000, page 1421] |
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| + | |||
| + | * [http://www.linuxjournal.com/article/3459 Automated Imaging Microscope System, Linux Journal 2000, Issue 70, February, Page 32-35] |
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Revision as of 10:30, 2 December 2007
The Aging Research Centre (ARC) is an independent non-profit educational research centre with facilities in Berkeley, California and in Waterloo, Ontario, Canada. Founded in 1994, it focuses its research in three areas: (1) the assembling and linking together of existing knowledge with respect to the aging process in animals, (2) engaging in experiments that shed light on the neuroendocrinology of aging, and the (3) creation of new tools that allow researchers to study the aging process.
Throughout the years, researchers at the Aging Research Centre have presented their research results at many conferences and published numerous articles ranging from the effects of caloric restriction on the cell density in the pre-optic hypothalamus, to the systems biology of aging, to articles on an Automated Imaging Microscope System (AIMS) that was developed by ARC researchers in collaboration with researchers at the University of California, Berkeley.